Non-coding RNAs (ncRNAs) function at the transcriptional and post-transcriptional levels to regulate gene expression. Some ncRNAs appear to be involved in epigenetic processes. They have been shown to play a significant role in heterochromatin formation, histone modification, DNA methylation targeting, and gene silencing. Non-coding RNAs have been found to interact with chromatin to influence gene transcription, possibly through RNA association with chromatin remodeling complexes or direct interaction with DNA. chirp (chromatin isolation by RNA purification), chart (capture hybridization analysis of RNA targets), ChOP (chromatin oligo affinity precipitation), and RAP (RNA antisense purification) are techniques that help to interpret long non-coding RNA (lncRNA)-chromatin interactions. More recently, more methods have been proposed to capture global RNA-DNA interactions. CHAR-Seq, SPRITE, and MARGI.
We provide a full range of RNA research technologies to help analyze the gene expression patterns, examine changes in the transcriptome, DNA-RNA interaction, and detect novel RNA molecules, mutations, and gene fusions, enabling a deeper understanding of RNA biology and disease development. In addition to NGS, we provide comprehensive RNA research technologies such as degradome profiling, CHIP-Seq, Ribo-Seq, and more.
State-of-the-art technologies coupled with next-generation sequencing to bring you comprehensive RNA research services
Examine the sequences, quantity, and interactions of ncRNA molecules
A full range of non-coding RNA sequencing solutions to satisfy your specific needs
Superior data quality: ≥80% bases with ≥Q30, >90% on average
Rigorous quality control and fast turn-around times
High-quality bioinformatics analysis in an efficient and customizable way
Explore how our innovate technologies help you understand ncRNA dynamics via transcriptomic and bioinformatic insights.
Degradome sequencing detect microRNA, a class of endogenous non-coding small RNA with of about 22 nt in length, some of which may participate in the regulation of alternative splicing or protein translation.