RNA and its associated interactions are widely involved in a variety of physiological and pathological processes and play an important role in life activities. In particular, non-coding RNAs, specific to their interactions with each other and with DNA and proteins, are essential components for processing cellular information. CD Genomics is dedicated to resolving the mechanisms involved in the interactions of RNA with other living molecular complexes by providing an omics-based approach.

Overview

Non-coding RNA (ncRNA), including long ncRNA (lncRNA), microRNA (miRNA), and small interfering RNA (siRNA), etc., participate in and contribute to the interactions of protein, RNA, and DNA. Patterns of intramolecular and intermolecular base pairs govern most RNA interactions. RNA analysis is often much more difficult because it is relatively small and highly susceptible to degradation and contamination. We customize a variety of solutions for you to resolve RNA biology, the functions of different RNAs and the mechanisms involved in molecular regulation. In addition, our many years of research experience can facilitate you to gain new insights into projects such as disease mechanism research, biomarker discovery, and drug development.

Service Portfolio

Explore how our interactive RNA solutions help researchers profile RNA and explore their pathways.

RNA-RNA Interactions (RRI)

The interactions between RNA molecules are very complex. Both small RNA (especially miRNA) and long coding and non-coding RNAs contain structural domains that can sense and bind other RNAs through complementary base pairing. The versatility of interactions confers multiple roles to RNA-RNA complexes, ranging from controlling RNA biogenesis to competing for common targets. We offer comprehensive RNA interaction analysis solutions including lncRNA-mRNA interactions, lncRNA-miRNA interactions and mRNA-lncRNA-miRNA (MLMI) networks through sequencing and other means.

RNA-Protein Interactions (RPI)

RNA can also interact directly with RNA-binding proteins (RBPs) to precisely and finely regulate activities, including processes such as transcription, RNA transport, RNA maturation, and stability. Approximately, 1-2% of the human genome encodes proteins, but as much as 83-85% of those are transcribed into RNA, implying the diversity of transcript functions and the complexity of regulatory mechanisms. Therefore, our RPI solutions with RNA as the entry point can gain new insights into the importance and dynamics of RNA-protein interactions in cells. Not only the interactions between RNA and RBP of interest can be discovered, but also the mechanisms of interactions useful for disease development and therapeutic studies can be found.

RNA-DNA Interactions

LncRNAs are involved in a variety of biological processes, including chromatin organization and transcriptional regulation, and act as structural scaffolds for nuclear structural domains. Studies have shown that lncRNAs bind to proximal or distal genomic regions and activate or repress transcription by recruiting co-activators or co-repressor proteins. We help you identify RNA-DNA interactions and explore the underlying mechanisms.

Application Fields

• Oncology research
• Drug and biomarker development
• Cellular regulation research

Reference:

1. Guil S, Esteller M. RNA–RNA interactions in gene regulation: the coding and noncoding players. Trends in biochemical sciences, 2015, 40(5): 248-256.