RNA Sequencing Solution for Drug Research and Development
The discovery and development of new drugs is a multidisciplinary and systematic effort. High-throughput sequencing technologies have greatly facilitated the discovery of biomarkers and drug targets in many diseases. RNA sequencing-based transcriptome studies can demonstrate the function and structure of genes at a holistic level and reveal the molecular mechanisms of disease-specific biological processes, as well as investigate the spatiotemporal gene expression in specific tissues or cells. High-throughput RNA sequencing, with its high throughput, high resolution, high sensitivity and low cost, is increasingly used for drug screening and drug mechanism studies.
Accelerate Research and Practice in Drug Research & Development
RNA-Seq is a powerful tool for analyzing gene structure and function at the transcriptome level. It enables the identification of differentially expressed transcripts involved in specific biological processes and helps uncover novel molecular mechanisms underlying complex phenotypes. RNA-Seq can also highlight critical genes and pathways relevant to biological responses, supporting research into potential molecular targets and mechanisms of action. In addition, it is widely used to study gene expression changes induced by compounds and to explore genetic factors related to compound sensitivity or resistance.
Compared with conventional bulk RNA-Seq, advanced approaches such as high-resolution transcriptome profiling can offer more detailed insights into gene expression heterogeneity, providing additional value in early-stage compound screening and biomarker research.
Leveraging advanced high-throughput sequencing platforms, CD Genomics offers comprehensive RNA sequencing solutions to support drug research and development. We provide end-to-end services including high-quality nucleic acid extraction from a wide range of sample types, followed by Illumina short-read sequencing, PacBio SMRT sequencing, and Nanopore direct RNA sequencing. Our robust bioinformatics pipelines further enable in-depth transcriptomic analysis, delivering customized reports to accelerate your scientific discoveries.
Our advantages
An abundance of sample handling experience
Multiple sequencing platforms to choose from
High accuracy of sequencing results
Comprehensive bioinformatics analysis and customized analysis
Long-term cooperation with bioindustry clients
The issues that can be addressed with our RNA sequencing services
Discovery of the molecular mechanism in diseases
Identification of drug-target genes and drug re-purpose
Identification of Genes Involved in the Drug Resistance and Sensitivity
Drug resistance research
Toxicity profiling with transcript analysis
Development of RNA therapeutics
Note: Our services are for research use only, not for disease diagnosis and treatment.
What can we do?
Sequencing targets: mRNA, tRNA, miRNAs, piRNA, snoRNA, IncRNA, circRNA
Sample types: various sample types such as urine, saliva, serum or blood, and tissues
Data delivery: identification, quantitation, differential expression analysis, and other bioinformatics analyses
Service Workflow
Sequencing Platforms
| Illumina NextSeq/HiSeq/NovaSeq |
PacBio RS IL / Sequel |
Nanopore |
Identification of potential drug target genes
Detecting differentially expressed alleles of transcripts
Splice variation |
Gene expression
Transcript structures
Drug target gene discovery
Splicing / alternative splicing
Transcription initiation
RNA cleavage / adenylation |
Gene expression
Transcript structures
Drug target gene discovery
Splicing / alternative splicing
Transcription initiation
RNA cleavage / adenylation
RNA modification |
Drug Research & Development with RNA-Seq
| ANALYSIS CONTENTS |
DETAILS |
| Drug target identification and validation |
Drug target identification and prioritization based on gene-disease associations; target druggability predictions; identification of alternative targets (splice variants). |
| Drug sensitivity analysis |
Conduct gene polymorphism and expression profile analysis to explore the impact of gene polymorphism on drug sensitivity and provide a basis for individualized medical treatment. |
| Differential transcript expression analysis |
Analysis of the functions of differentially expressed transcripts and discovery of pharmacological mechanisms of action. |
| Other advanced Analysis |
In-depth and advanced analyses: Gene fusion analysis, single nucleotide variant analysis, ncRNA-gene interaction network. |
Comprehensive Solutions to Accelerate Drug Research & Development
CD Genomics has a professional technical team and bio-analysis team, and has more than ten years of project experience in the sequencing field. We have a mature technical route, provide accurate and reliable data and deliver results that meet your requirements. We are committed to providing efficient, cost-effective, and high-quality sequencing services for drug research and development.
* For Research Use Only. Not for use in diagnostic procedures.
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