RNAs can be modified post-transcriptionally with dynamic and reversible modifications such as N6-methyladenosine (m6A). RNA methylation dynamically regulates the processing, export, translation, and stability of RNA molecules, thereby affecting biological and pathological processes such as differentiation and cellular response to stress and tumorigenesis. Epitranscriptomics refers to the field that studies RNA modifications. The majority of RNA modifications involve the addition of a methyl group to certain positions on the RNA such as m6A, N1-methyladenosine (m1A), 5-methylcytosine (m5C) and 2'-O-methylation. Sometimes, acetylation also occurs on RNA molecules. Next-generation sequencing (NGS)-based methods, either relying on antibody enrichment or third-generation sequencing, have been developed to map post-transcriptional RNA modification and explore their functions, We provide a full range of epitranscriptomics services to investigate RNA modifications using NGS or long-read sequencing (Oxford nanopore sequencing and PacBio SMRT sequencing). We can help you detect many forms of RNA modifications including m7G, m3C, m1A, 5mC, 5hmC, m6A, m6Am, acetylation, and 2'-O-methylation.
Single-base resolution and high throughput
Cover mRNA, lncRNA, pri-miRNA, tRNA, rRNA and other RNAs
Rigorous quality control and fast turn-around times
Professional bioinformatics analysis in an efficient and customizable way
Explore how our epitranscriptomics services help researchers map RNA modifications and explore their pathways.